Go straight to H7N9 avian influenza articles

The A(H7N9) virus

Influenza A H7 viruses are a group of influenza viruses that normally circulate among birds. The influenza A(H7N9) virus is one subgroup among the larger group of H7 viruses. Although some H7 viruses (H7N2, H7N3 and H7N7) have occasionally been found to infect humans, no human infections with H7N9 viruses have been reported until March 2013, when three urban residents of Shanghai or Anhui, China, presented with rapidly progressing lower respiratory tract infections and were found to be infected with a novel reassortant avian-origin influenza A (H7N9) virus.

Developing a vaccine

There is currently no vaccine for the prevention of avian influenza A(H7N9) infections although at least four biopharmaceutical companies have candidates that are being tested in animal and human trials. (Wu YL, Shen L-W, Ding Y-P. Preliminary success in the characterization and management of a sudden breakout of a novel H7N9 influenza A virus. International Journal of Biological Sciences, 2014, volume 10, number 1, pages 109-118. Full text : Bart SA. et al. A Cell Culture–Derived MF59-Adjuvanted Pandemic A/H7N9 Vaccine Is Immunogenic in Adults. Sci Transl Med 30 April 2014: Vol. 6, Issue 234, p. 234ra55
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General Resources

WHO

Avian influenza A(H7N9) virus

Avian Influenza A(H7N9) Response:An Investment in Public Health Preparedness

Hong Kong Centre for Health Protection (CHP)

Avian influenza

Weekly avian influenza report

Chinese Center for Disease Control and Prevention

H7N9

Weekly updates

Frequently asked questions

Research highlights

Dr Ian M Mackay

Virology Down Under

Influenza Specialist Group, Australia

H7N9 Summary

 

Recent Journal Articles

Fan J. et al. Detection of a novel avian influenza A (H7N9) virus in humans by multiplex one-step real-time RT-PCR assay. BMC Infect Dis. 2014 Oct 8;14(1):541.
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Jin W. et al. Three Cases of Avian-origin Influenza A (H7N9) Virus Infection in Zhejiang Province, China: Case Report and Literature Review. Intern Med. 2014;53(20):2397-400.
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Ma X. et al. Knowledge, attitudes and practices relating to influenza A(H7N9) risk among live poultry traders in Guangzhou City, China. BMC Infect Dis. 2014 Oct 18;14(1):554.
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Mulligan MJ. et al. Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial. JAMA. 2014 Oct 8;312(14):1409-19.
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Nailwal H1, Kamra K, Lal SK. H7N9: A killer in the making or a false alarm? Can J Microbiol. 2014 Jul;60(7):425-9.
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Wang XY. et al. Epidemiology of human infections with avian influenza A(H7N9) virus in the two waves before and after October 2013 in Zhejiang province, China. Epidemiol Infect. 2014 Oct 7:1-7.
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Wu J. et al. Serologic screenings for H7N9 from three sources among high-risk groups in the early stage of H7N9 circulation in Guangdong Province, China. Virol J. 2014 Oct 23;11(1):184.
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Xiao YY. et al. Prognosis and survival of 128 patients with severe avian influenza A(H7N9) infection in Zhejiang province, China. Epidemiol Infect. 2014 Oct 31:1-6.
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Yang Y. et al. Novel Avian-Origin Influenza A (H7N9) in Critically Ill Patients in China. Crit Care Med. 2014 Oct 31.
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Yi L. et al. Family Clusters of Avian Influenza A H7N9 Infection in Guangdong Province, China. J Clin Microbiol. 2014 Oct 22. pii: JCM.02322-14.
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April - October 2014

Chen Z. et al. Detection of Avian Influenza A(H7N9) Virus from Live Poultry Markets in Guangzhou, China: A Surveillance Report. PLoS One. 2014 Sep 12;9(9):e107266.
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Chen Z, Liu H, Lu J, et al. Asymptomatic, mild, and severe influenza A(H7N9) virus infection in humans, Guangzhou, China. Emerg Infect Dis 2014 (published online Aug 14)
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Dong L. et al. A Combination of Serological Assays to Detect Human Antibodies to the Avian Influenza A H7N9 Virus. (China) PLoS One. 2014 Apr 22;9(4):e95612.
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Fan J. et al. Detection of a novel avian influenza A (H7N9) virus in humans by multiplex one-step real-time RT-PCR assay. BMC Infect Dis. 2014 Oct 8;14(1):541.
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Fuller T. et al. Identifying areas with a high risk of human infection with the avian influenza A (H7N9) virus in East Asia. J Infect. 2014 Aug;69(2):174-81.
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Gao GF. Influenza and the live poultry trade. Science. 2014 Apr 18;344(6181):235.

Gao R. et al. Ultrastructural characterization of avian influenza A (H7N9) virus infecting humans in China. Virol Sin. 2014 Apr;29(2):119-22.

He Y. et al. Live Poultry Market Closure and Control of Avian Influenza A(H7N9), Shanghai, China. Emerg Infect Dis. 2014 Sep;20(9):1565-6.
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Jin W. et al. Three Cases of Avian-origin Influenza A (H7N9) Virus Infection in Zhejiang Province, China: Case Report and Literature Review. Intern Med. 2014;53(20):2397-400.
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Kang X. et al. Detection of Avian influenza A/H7N9/2013 virus by Real-Time Reverse Transcription-Polymerase Chain Reaction. J Virol Methods. 2014 May 28. pii: S0166-0934(14)00128-1.
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Ke C. et al. Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong province, China, 2013. Emerg Infect Dis 2014
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Khazeni N. et al. Health and Economic Benefits of Early Vaccination and Nonpharmaceutical Interventions for a Human Influenza A (H7N9) Pandemic: A Modeling Study. Ann Intern Med. 2014 May 20;160(10):684-94.
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Krammer F. et al. An H7N1 Influenza Virus Vaccine Induces Broadly Reactive Antibody Responses against H7N9 in Humans. Clin Vaccine Immunol. 2014 Aug;21(8):1153-63.
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Krammer F. et al. Divergent H7 Immunogens Offer Protection from H7N9 Virus Challenge. J Virol. 2014 Apr;88(8):3976-85.
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Liu B. et al. Risk Factors for Influenza A(H7N9) Disease-China, 2013. Clin Infect Dis. 2014 Sep 15;59(6):787-94.
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Liu C. et al. Extracorporeal membrane oxygenation as rescue therapy for H7N9 influenza-associated acute respiratory distress syndrome. Chin Med J 2014 May;127(9):1798.
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Lu J. et al.
Genetic changes of reemerged influenza A(H7N9) viruses, China. Emerg Infect Dis 2014 (published online May 23)
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Ma X. et al. Knowledge, attitudes and practices relating to influenza A(H7N9) risk among live poultry traders in Guangzhou City, China. BMC Infect Dis. 2014 Oct 18;14(1):554.
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Mao C. et al. An Internet-Based Epidemiological Investigation of the Outbreak of H7N9 Avian Influenza A in China Since Early 2013. J Med Internet Res. 2014 Sep 25;16(9):e221.
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Mulligan MJ. et al. Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial. JAMA. 2014 Oct 8;312(14):1409-19.
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Nailwal H1, Kamra K, Lal SK. H7N9: A killer in the making or a false alarm? Can J Microbiol. 2014 Jul;60(7):425-9.
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Pantin-Jackwood MJ. et al. Role of poultry in the spread of novel H7N9 influenza virus in China. J Virol. 2014 May;88(10):5381-90.
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Qiao JG. et al. Management of the First Confirmed Case of Avian Influenza A H7N9. Respir Care. 2014 Apr;59(4):e43-6.
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Shen Y, Lu H. Human infection with avian influenza A(H7N9) virus in Shanghai: current status and future trends. Chin Med J. 2014 May;127(10):1973-6.
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Si Y. et al. Entry Properties and Entry Inhibitors of a Human H7N9 Influenza Virus. PLoS One. 2014 Sep 15;9(9):e107235.
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Su S. et al. Virological and Epidemiological Evidence of Avian Influenza Virus Infections Among Feral Dogs in Live Poultry Markets, China: A Threat to Human Health? Clin Infect Dis. 2014 Apr 4. [Epub ahead of print]
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Sun J. et al. Comparison of Characteristics between Patients with H7N9 Living in Rural and Urban Areas of Zhejiang Province, China: A Preliminary Report. PLoS One. 2014 Apr 7;9(4):e93775.
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To KK, Chan JF, Yuen KY. Viral lung infections: epidemiology, virology, clinical features, and management of avian influenza A(H7N9). Curr Opin Pulm Med. 2014 May;20(3):225-32.
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Wang L. et al. Human exposure to live poultry and psychological and behavioral responses to influenza A(H7N9), China. Emerg Infect Dis 2014 (published online May 28)
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Wang W. et al. PCR for detection of oseltamivir resistance mutation in influenza A(H7N9) virus. Emerg Infect Dis. 2014 May;20(5):847-9.
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Wang W. et al. Serologic assay for avian-origin influenza A (H7N9) virus in adults of Shanghai, Guangzhou and Yunnan, China. J Clin Virol 2014 (published online Apr 13)
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Wang X. et al. Seroprevalence to avian influenza A(H7N9) virus among poultry workers and the general population in southern China: a longitudinal study. Clin Infect Dis 2014 (published online May 27)
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Wang XY. et al. Epidemiology of human infections with avian influenza A(H7N9) virus in the two waves before and after October 2013 in Zhejiang province, China. Epidemiol Infect. 2014 Oct 7:1-7.
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Wang YR, Li JM, Wang XF. Clinical and epidemiological analysis of the first case of human infection with avian influenza A (H7N9) virus in Shenzhen, China. Int J Infect Dis. 2014 Aug;25:177-9.
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Wu J. et al. Serologic screenings for H7N9 from three sources among high-risk groups in the early stage of H7N9 circulation in Guangdong Province, China. Virol J. 2014 Oct 23;11(1):184.
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Wu P. et al. Responses to threat of influenza A(H7N9) and support for live poultry markets, Hong Kong, 2013. Emerg Infect Dis. 2014 May;20(5):882-6.
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Xiao YY. et al. Prognosis and survival of 128 patients with severe avian influenza A(H7N9) infection in Zhejiang province, China. Epidemiol Infect. 2014 Oct 31:1-6.
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Xie T. et al. Correlation between reported human infection with avian influenza A H7N9 virus and cyber user awareness: what can we learn from digital epidemiology? Int J Infect Dis. 2014 May;22:1-3.
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Yang Y. et al. Novel Avian-Origin Influenza A (H7N9) in Critically Ill Patients in China. Crit Care Med. 2014 Oct 31.
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Yi L. et al. Family Clusters of Avian Influenza A H7N9 Infection in Guangdong Province, China. J Clin Microbiol. 2014 Oct 22. pii: JCM.02322-14.
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Zeng X. et al. Mild influenza A/H7N9 infection among children in Guangdong Province. Pediatr Infect Dis J 2014 (published online Jul 25)
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Zhang J. et al. Determination of original infection source of H7N9 avian influenza by dynamical model. Sci Rep. 2014 May 2;4:4846.
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Zhang J, Chen Y. Patients infected with avian influenza A H7N9 virus have abnormally low thyroid hormone levels. Clin Lab. 2014;60(7):1241-3.
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Zhang J, Zhao Y, Chen Y. Laboratory findings in patients with avian-origin influenza A (H7N9) virus infections. J Med Virol. 2014 May;86(5):895-8.
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Zhang Y. et al. Isolation and characterization of H7N9 avian influenza A virus from humans with respiratory diseases in Zhejiang, China. Virus Res. 2014 May 24. pii: S0168-1702(14)00183-X.
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Zhu G, Peterson AT. Potential Geographic Distribution of the Novel Avian-Origin Influenza A (H7N9) Virus. PLoS One. 2014 Apr 1;9(4):e93390.
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H7N9 Avian Influenza Bibliography April 2013 - April 2014