APACI is governed by a Board of Directors, in compliance with the Articles of Association as set down by the Companies Ordinance, Chapter 32 of the laws of Hong Kong.

The inaugural Directors are Associate Professor Lance Jennings, Clinical Professor David Smith, and Professor Paul Chan. On 3 February 2014, Dr John Tam became the 4th APACI Director. 

Day to day management of the organization is undertaken by APACI's Executive Director, Mr Kim Sampson.

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Kim has more than 30 years of experience in management and finance in the fields of medical and scientific research, public and private health, and community services. Kim joined APACI in the inaugural role in April 2011.

He is also the Chief Executive Officer of the Influenza Specialist Group of Australia, as well as their Company Secretary.

Kim is also the current President of the Australia-Vietnam Friendship Society.